PUBLICATIONS FROM HALDAR LAB

 

2017

Stratton MS, Haldar SM, McKinsey TA. BRD4 inhibition for the treatment of pathological organ fibrosisF1000Res. 2017 Jun 28;6. pii: F1000 Faculty Rev-1015. doi: 10.12688/f1000research.11339.1. eCollection 2017.

Duan Q, McMahon S, Anand P, Shah H, Thomas S, Salunga HT, Huang Y, Zhang R, Sahadevan A, Lemieux ME, Brown JD, Srivastava D, Bradner JE, McKinsey TA, Haldar SM. BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure. Sci Transl Med. 2017 May 17;9(390). pii: eaah5084. doi: 10.1126/scitranslmed.aah5084. 

Link to the full article.

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2016

Stratton MS, Lin CY, Anand P, Tatman PD, Ferguson BS, Wickers ST, Ambardekar AV, Sucharov CC, Bradner JE, Haldar SM, McKinsey TA. Signal-Dependent Recruitment of BRD4 to Cardiomyocyte Super-Enhancers Is Suppressed by a MicroRNA. Cell Rep. 2016 Jul 13. pii: S2211-1247(16)30843-9. doi: 10.1016/j.celrep.2016.06.074. [Epub ahead of print]

Haldar SM, Srivastava D. Sarcomeres and Cardiac Growth: Tension in the RelationshipTrends Mol Med 2016. pii: S1471-4914(16)30025-9. doi: 10.1016/j.molmed.2016.05.001.

 

2015

Morrison-Nozik A, Anand P, Duan Q, Sabeh M, Zhu H, Prosdoscimo DA, Nordsborg NB, Russell AP, Gerber AN, Macrae C, Jain MK, Haldar SMGlucocorticoids Enhance Muscle Endurance and Ameliorate Duchenne Muscular Dystrophy through a Defined Metabolic ProgramProc Natl Acad Sci U S A 2015; 112(49):E6780-9

Featured in: Faculty of 1000 (F1000)

Milstone DS, Ilyama M, Chen M, O’Donnell P, Davis VM, Brown JD, Haldar SM, Siu A, Lau AC, Su-Ning Zhu, Basheer MF, Jongstra-Bilen J, Collins T, Cybulsky MI. Differential Role of a NF-κB Transcriptional Response Element in Endothelial versus Intimal Cell VCAM-1 ExpressionCirculation Research 2015; 117(2):166-77.

Duan Q, Madan ND, Wu J, Kalisz, Doshi KY, Haldar SM, Pierre SV. Role of PI3K-IA Activation in Cardioprotection Induced by Ouabain PreconditioningJ Mol Cell Cardiol 2015; 80:114-25.

Tandler B, Fujioka H, Hoppel CL, Haldar SM, Jain MK. Megamitochondria in Cardiomyocytes of a Knockout (Klf15-/-) MouseUltrastructural Pathology 2015; Jun 25:1-4.

 

2014

Prosdocimo DA, Anand P, Liao X, Zhu H, Shelkay S, Artero Calderon P, Zhang L, Kirsh J, Moore D, Rosca MG, Vazquez E, Kerner J, Akat KM, Williams Z, Zhao J, Fujioka H, Tuschl T, Bai X, Schulze CP, Hoppel CL, Jain MK*, Haldar SMKruppel-like Factor 15 is a Critical  Regulator of Cardiac Lipid MetabolismJ Biol Chem 2014; 289(9):5914-24.

DiSalvo T, Haldar SMEpigenetic Mechanisms in Heart Failure PathogenesisCirculation Heart Failure 2014; 7(5):850-63.

Haldar SM*, McKinsey TA*. BET-ting on chromatin-based therapeutics for heart failureJ Mol Cell Cardiol 2014; 74:98-102.

 

2013

Anand P, Brown JD, Lin CY, Qi J, Zhang R, Artero-Calderon P, Alaiti MA, Bullard J, Alazem K, Margulies KB, Cappola TP, Lemieux M, Plutzky J, Bradner JE*, Haldar SM*. BET Bromodomains Mediate Transcriptional Pause Release in Heart FailureCell 2013; 154(3):569-582. 

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Sasse SK, Mailloux CM, Barczak AJ, Wang Q, Altonsy MO, Jain MK, Haldar SM, Gerber AN. The glucocorticoid receptor and KLF15 regulate gene expression dynamics and integrate signals through feed forward circuitryMol Cell Biol 2013; 33(11):2104-2115.

Haldar SM, Stamler JS. S-nitrosylation: integrator of cardiovascular performance and oxygen deliveryJournal of Clinical Investigation 2013; 123(1):101-10.

Fujioka H, Tandler B, Haldar SM, Jain MK, Hoppel CL. String mitochondria in mouse soleus muscleMicrosc Res Tech 2013; 76(3):237-41.

 

2012

Haldar SM, Jeyaraj D, Anand P, Zhu H, Lu Y, Prosdocimo DA, Eapen B, Kawanami D, Okutsu M, Brotto L, Fujioka H, Kerner J, Rosca MG, McGuinness OP, Snow RJ, Russell AP, Gerber AN, Bai X, Yan Z, Nosek TM, Brotto M, Hoppel CL, Jain MK. Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptationProc Natl Acad Sci U S A 2012; 109(17):6739-44.

Jeyaraj D, Scheer FA, Ripperger JA, Haldar SM, Lu Y, Prosdocimo DA, Eapen SJ, Eapen BL, Cui Y, Mahabeleshwar GH, Lee HG, Smith MA, Casadesus G, Mintz EM, Sun H, Wang Y, Ramsey KM, Bass J, Shea SA, Albrecht U, Jain MK. Klf15 orchestrates circadian nitrogen homeostasisCell Metabolism 2012; 15(3):311-23.

Jeyaraj D, Haldar SM, Wan X, McCauley MD, Ripperger JA, Hu K, Lu Y, Eapen BL, Sharma N, Ficker E, Cutler MJ, Gulick J, Sanbe A, Robbins J, Demolombe S, Kondratov RV, Shea SA, Albrecht U, Wehrens XH, Rosenbaum DS, Jain MK. Circadian rhythms govern cardiac  repolarization and arrhythmogenesisNature 2012; 483(7387):96-9.

Featured in: Circulation Research

 

2011

Mahabeleshwar GM, Kawanami D, Sharma N, Takami Y, Zhou G, Shi H, Nayak L, Jeyaraj D, Grealy R, White M, McManus R, Ryan T, Lin Z, Haldar SM, Atkins GB, Wong HR, Lingrel JB, and Jain MK.  The myeloid transcription factor KLF2 regulates the host response to polymicrobial infection and endotoxic shockImmunity 2011; 34(5):715-28.

Masuno K, Haldar SM, Jeyaraj D, Mailloux C, Huang X, Panettieri RA Jr, Jain MK, and Gerber AN. Expression profiling identifies Klf15 as a glucocorticoid target that regulates airway hyperresponsivenessAm J Resp Cell Mol Biol 2011; 45(3):642-9.

 

2010

Lu Y, Haldar S, Croce K, Wang Y, Sakuma M, Morooka T, Wang B, Jeyaraj D, Gray SJ, Simon DI, Jain MK. Kruppel-like factor 15 regulates smooth muscle response to vascular injuryArterioscler Thromb Vasc Biol 2010; 30(8):1550-2.

Liao X, Haldar SM, Lu Y, Jeyaraj D, Paruchuri K, Nahori M, Cui Y, Kaestner KH, Jain MK. Kruppel-like Factor 4 regulates pressure-induced cardiac hypertrophyJ Mol Cell Cardiol  2010; 49(2):334-8.

Haldar SM, Lu Y, Jeyaraj D, Kawanami D, Cui Y, Eapen SJ, Hao C, Li Y, Doguman YQ, Watanabe M, Shimizu K, Sadoshima J, Margulies KB, Cappola TP, Jain MK. Kruppel-like Factor 15 is a Molecular Link Between Heart Failure and Aortic Aneurysm FormationScience Translational Medicine 2010; 2(26):26ra26.

 

2009 and before

Kawanami D, Mahabeleshwar GH, Lin Z, Atkins GB, Hamik A, Haldar SM, Maemura K, LaManna JC, and Jain MK. Kruppel-like Factor 2 Inhibits Hypoxia-inducible Factor-1a Expression and Function in the EndotheliumJ Biol Chem 2009; 284(31): 20522-30.

Wang B, Haldar SM, Lu Y, Ibrahim OA, Fisch S, Gray S, Leask A, and Jain MK. The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblastsJ Mol Cell Cardiol 2008; 45(2):193-7.

Gray S, Wang B, Orihuela Y, Hong EG, Fisch S, Haldar S, Cline GW, Kim JK, Peroni OD, Kahn BB, and Jain MK. Regulation of gluconeogenesis by Krüppel-like factor 15 (KLF15)Cell Metabolism 2007; 5(4):305-12.

Haldar SM, Ibrahim OA, Jain MK. Kruppel-Like Factors (KLFs) in Muscle BiologyJ Mol Cell Cardiol 2007;43(1):1-10.

Fisch S, Gray S, Heymans S, Haldar SM, Wang B, Pfister O, Cui L, Kumar A, Lin Z, Sen-Banerjee S, Das H, Petersen CA, Mende U, Burleigh BA, Zhu Y, Pinto Y, Liao R and Jain MK. Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophyProc Natl Acad Sci U S A 2007; 104(17):7074-9.

Haldar SM, O’Gara PT. Infective Endocarditis: Diagnosis and Management. Nature Clinical Practice – Cardiovascular Medicine 2006; 3(6): 310-317.

Champion HC, Georgakopoulos D, Haldar S, Wang L, Wang Y, Kass DA. Robust Adeno-and Adeno-Associated Viral Gene Transfer to the in vivo Murine Heart: Application Study of in vivo Phospholambam PhysiologyCirculation 2003; 108: 2790-2797.

Peng X, Haldar S, Deshpande S, Irani K, Kass DA. Wall Stiffness Suppresses Akt/eNOS and Cytoprotection in Pulse-perfused EndotheliumHypertension 2003; 41: 378-81.

Bernier SG, Haldar S, Michel T. Bradykinin Regulated Interactions of the Mitogen-activated Protein Kinase Pathway with the Endothelial Nitric-oxide SynthaseJ Biol Chem 2000; 275: 30707-15.